Producer: Boehringer Ingelheim
Sterile Triamcinolone Acetonide Suspension USP
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NADA 012-198, Permitted by FDA
Vetalog Parenteral Veterinary Warning
Federal regulation restricts this drug to make use of by or on the order of a licensed veterinarian.
Vetalog Parenteral is out there for veterinary use as a sterile suspension in vials offering 2 mg or 6 mg triamcinolone acetonide per mL with 0.9% (w/v) benzyl alcohol as a preservative, sodium chloride for isotonicity, 0.75% carboxymethylcellulose sodium and 0.04% polysorbate 80. Sodium hydroxide or hydrochloric acid might have been added to regulate the pH. On the time of manufacture, the air within the container is changed by nitrogen.
Actions: Triamcinolone acetonide is a extremely potent artificial glucocorticoid which is primarily efficient due to its anti-inflammatory exercise. The obvious analgesic impact is a results of the anti-inflammatory properties of the drug.
Rationale For Use: Irritation and associated problems: Canine, Cats and Horses: Injection of Vetalog Parenteral supplies speedy reduction from ache and reduces irritation and swelling.
Relying on the character of the situation, Vetalog Parenteral could also be injected intramuscularly, intra-articularly or intrasynovially. The standard sample of response is enchancment of movement and reduce of ache inside 24 hours, adopted by diminution of swelling.
The extent of return to regular is proscribed by the diploma of irreversible pathologic change current. Triamcinolone acetonide won’t reverse everlasting pathologic adjustments.
Allergic and Dermatologic Problems: Canine and Cats: Intramuscular or subcutaneous administration of Vetalog Parenteral has been discovered to offer immediate and extended reduction within the administration of allergic signs akin to conjunctivitis or reactions to insect bites and in numerous dermatoses. Irritation, edema and pruritus are suppressed and discomfort is eased, often inside 24 hours. Since scratching is diminished or eradicated, lesions are permitted to heal extra quickly. In lots of instances a single injection is enough to terminate symptomatology. If crucial, repeat therapies may be administered.
Intralesional administration of Vetalog Parenteral is efficient for therapy of dermatological problems akin to moist eczema, frictional acanthosis and different dermatitides in canine and cats. Irritation and pruritus are sometimes abated inside one to 3 days. A single intralesional injection is commonly enough to impact remission or elimination of the lesion inside a interval of 1 to 2 weeks.
Vetalog Parenteral Veterinary Indications
Vetalog Parenteral is indicated for the therapy of irritation and associated problems in canine, cats and horses. It’s also indicated to be used in canine and cats for the administration and therapy of acute arthritis, allergic and dermatologic problems.
Dosage and Administration: Intramuscular or subcutaneous: Canine and Cats: The dose is a single injection of 0.05 mg to 0.1 mg triamcinolone acetonide per pound of physique weight in inflammatory or allergic problems and 0.1 mg per pound of physique weight in dermatologic problems. Remission of signs, if not everlasting, often lasts 7 to fifteen days. After this time, if signs recur, the dose could also be repeated or oral corticosteroid remedy could also be instituted.
Horses: The dose is 0.01 mg to 0.02 mg triamcinolone acetonide per pound of physique weight as a single injection; the standard vary is 12 mg to twenty mg.
Intralesional: Canine and Cats: The standard intralesional dosage is 1.2 mg to 1.8 mg triamcinolone acetonide. Injections must be circumscribed across the lesion in numerous websites to insure enough distribution of the dose. Injections must be spaced 0.5 cm to 2.5 cm aside, relying on the scale of the lesion. The spacing of the dose additionally reduces ache and/or stress necrosis.
The dose injected at anyone web site mustn’t exceed 0.6 mg to attenuate native tissue intolerance and atrophy, and must be made properly into the cutis to stop subsequent rupture of the dermis. When treating canine and cats with a number of lesions, don’t exceed a complete dose of 6 mg. Repeat programs of therapy could also be administered if crucial.
It’s preferable to make use of a tuberculin syringe with a small bore needle (23-25 gauge) for accuracy of dose measurement and ease of administration.
Intra-articular and intrasynovial: Canine, Cats and Horses: The dose for intra-articular or intrasynovial administration depends on the scale of the joint to be handled and on the severity of signs. A single injection of 1 mg to three mg triamcinolone acetonide for cats and canine and 6 mg to 18 mg for horses is advisable. After three or 4 days, injections could also be repeated, relying on the severity of signs and the medical response. If preliminary outcomes are insufficient or too transient, dosage could also be elevated, however the advisable dose shouldn’t be exceeded.
Routine aseptic preparation of the realm must be made previous to all intra-articular injections. An intensive understanding of the pertinent anatomic relationships is crucial. The inadvertent administration of the corticosteroid into the tender tissues surrounding a joint will not be dangerous, however is the commonest reason for failure to attain the specified native outcomes.
Following intra-articular administration, ache and different native signs might proceed for a short while earlier than efficient reduction is obtained, however a rise in joint discomfort is uncommon. A marked improve in ache accompanied by native swelling, additional restriction of joint movement, fever and malaise are suggestive of a septic arthritis. If these problems ought to happen and the analysis of sepsis is confirmed, antimicrobial remedy must be instituted instantly and continued till all proof of an infection has disappeared.
Don’t use in viral infections. Apart from emergency remedy, don’t use in animals with tuberculosis, power nephritis, or cushingoid syndrome. Existence of congestive coronary heart failure, diabetes and osteoporosis are relative contraindications.
Don’t use in horses meant for human consumption.
Utilization in Being pregnant: The protection of most corticosteroid medication to be used throughout all levels of being pregnant has not been adequately established. Nevertheless, medical and experimental information have demonstrated that corticosteroids administered orally or by injection to animals might induce the primary stage of parturition if used over the last trimester of being pregnant and should precipitate untimely parturition adopted by dystocia, fetal dying, retained placenta and metritis.
Moreover, corticosteroids administered to canine, rabbits and rodents throughout being pregnant have resulted in cleft palate in offspring. Corticosteroids administered to canine throughout being pregnant have additionally resulted in different congenital anomalies together with deformed forelegs, phocomelia and anasarca. Subsequently, earlier than use of corticosteroids in pregnant animals, the potential advantages to the pregnant animal must be weighed towards potential hazards to its growing embryo or fetus.
Vetalog Parenteral shouldn’t be used to alleviate ache or scale back irritation arising from infectious states until concomitant antimicrobial remedy is given.
Due to the anti-inflammatory motion of corticosteroids, indicators of an infection could also be hidden and it could be essential to cease therapy till analysis is made.
Overdosage of some glucocorticoids might lead to sodium retention, fluid retention, potassium loss and weight positive factors.
Corticosteroids have been used within the therapy of laminitis; Vetalog Parenteral will not be advisable for that use. Instances of laminitis have been reported following the administration of Vetalog Parenteral; the mechanism of that response has not been absolutely elucidated. Care is critical when utilizing any corticosteroid within the equine species.
Use of corticosteroids, relying on dose, period and particular steroid, might lead to inhibition of endogenous steroid manufacturing following drug withdrawal. In sufferers presently receiving or lately withdrawn from systemic corticosteroid therapies, remedy with a quickly appearing corticosteroid must be thought of in unusually aggravating conditions.
As with every corticosteroid, polydipsia or polyuria might happen with excessive dosage or frequent administration of triamcinolone acetonide. The probability of their incidence could also be minimized by giving as temporary a course of corticosteroid remedy as potential, and by ready for the reappearance of signs earlier than repeating remedy. If polydipsia or polyuria ought to happen, remedy must be discontinued till these negative effects have disappeared; remedy ought to then be resumed at a decrease dosage stage.
Different adversarial reactions which have occurred with the usage of corticosteroids are weight reduction, anorexia and diarrhea (often bloody). Anaphylactoid reactions have often been seen following administration.
Intra-articular injection in leg accidents of the horse might produce osseous metaplasia.
Negative effects akin to serum alkaline phosphatase (SAP) and serum glutamic pyruvic transaminase (SGPT) enzyme elevations have occurred following use of artificial corticosteroids in canine.
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Cushing’s Syndrome in canine has been reported in affiliation with extended or repeated steroid remedy.
To report suspected adversarial reactions, or to acquire a replica of the Materials Security Information Sheet (MSDS), name 1-866-638-2226.
Vetalog Parenteral is provided for veterinary use in two concentrations and numerous vial sizes:
NDC 0981830117 – 2 mg/mL 100 mL (For Horses Solely)*
NDC 0981830117 – 2 mg/mL 25 mL
NDC 0981830117 – 6 mg/mL 25 mL (For Horses Solely)*
NDC 0981830117 – 6 mg/mL 5 mL
NDC 0981830117 – 6 mg/mL 3 mL (For Horses Solely)
*To restrict the variety of entries by the stopper, these two vials are to be used in HORSES ONLY
Retailer at managed room temperature 20-25°C (68-77°F), with excursions between 15-30°C (59-86°F) permitted. AVOID FREEZING. Defend from mild; retailer vial in carton.
Vetalog® is a registered trademark of Boehringer Ingelheim Vetmedica, Inc.
© 2013 Boehringer Ingelheim Vetmedica, Inc. All Rights Reserved.
Made in Italy
Manufactured for: Boehringer Ingelheim Vetmedica, Inc., St. Joseph, MO 64506 U.S.A.
470301-00 1134124A5, 470410-00 1134121A4 (for horses solely)
NAC No.: 1028236.1